| dc.contributor.advisor | Kopecký, Jan | |
| dc.contributor.author | Caisová, Veronika | |
| dc.date.accessioned | 2021-12-08T12:55:07Z | |
| dc.date.available | 2021-12-08T12:55:07Z | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-11-10 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/123456789/33857 | |
| dc.description.abstract | Imunoterapie se zda jako velmi efektivni lecba nadorovych onemocneni. Pri tomto typu terapie jsou nadorove bunky eliminovany telu vlastnimi imunitnimi bunkami s minimalnim negativnim efektem na zdravou tkan. Tato prace je zamerena na imunoterapii zalozenou na aktivaci vrozene imunity, konkretne na intratumoralni aplikaci fagocytozu stimulujicich ligandu a ligandu Toll-like receptoru. Tento terapeuticky pristup byl testovan u nekolika druhu nadorovych mysich modelu - melanom B16-F10, pankreaticky adenokarcinom a pheochromocytom. Slozeni terapeuticke smesi a davkovani terapeuticke smesi bylo optimalizovano v ramci teto prace. Zaroven byly zkoumany mechanismy zapojene v eliminaci nadoru v prubehu teto terapi. | cze |
| dc.format | 132 | |
| dc.format | 132 | |
| dc.language.iso | cze | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | immunoterapie | cze |
| dc.subject | nadory | cze |
| dc.subject | vrozena imunita | cze |
| dc.subject | ligandy stimulujici fagocytozu | cze |
| dc.subject | ligandy toll-like receptoru | cze |
| dc.subject | mysi nadorove modely | cze |
| dc.subject | neutrofily | cze |
| dc.subject | immunotherapy | eng |
| dc.subject | tumors | eng |
| dc.subject | innate immunity | eng |
| dc.subject | phagocytosis stimulating ligands | eng |
| dc.subject | toll-like receptors ligands | eng |
| dc.subject | mouse tumor models | eng |
| dc.subject | neutrophils | eng |
| dc.title | Studium nádorové imunoterapie založené na instalaci ligandů fagocytárních receptorů na nádorové buňky a objasnění probíhajících procesorů | cze |
| dc.title.alternative | The study of cancer immunotherapy based on installation of phagocytosis stimulating ligands on the tumor cells surface and investigation of underlying mechanisms | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 39613 | |
| dc.description.abstract-translated | Immunotherapy became a very promising approach for cancer therapy. Tumor cells are eliminated using the body's own immune system with minimal negative effect on healthy tissue. This thesis is focused on immunotherapy based on activation of innate immunity, specifically on intratumoral application of ligands stimulating phagocytosis and Toll-like receptor ligands. This therapeutic approach was tested in several types of tumor mouse models, such as melanoma B16-F10, pancreatic adenocarcinoma, and pheochromocytoma. The composition of the therapeutic mixture as well as the application schedule were optimized in our studies. Subsequently the underlying mechanisms involved in tumor elimination during this therapy were investigated. | eng |
| dc.date.accepted | 2017-12-13 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Infekční biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Eaten, John W. | |
| dc.contributor.referee | Říhová, Blanka | |
